Alphaviruses in Gene Therapy

Alphaviruses in Gene Therapy

Alphavirus vectors present an attractive approach for gene therapy applications due to the rapid and simple recombinant virus particle production and their broad range of mammalian host cell transduction. Mainly three types of alphavirus vectors, namely naked RNA, recombinant particles and DNA/RNA layered vectors, have been subjected to preclinical studies with the goal of achieving prophylacti...

Oncolytic Alphaviruses in Cancer Immunotherapy

Oncolytic viruses show specific targeting and killing of tumor cells and therefore provide attractive assets for cancer immunotherapy. In parallel to oncolytic viral vectors based on adenoviruses and herpes simplex viruses, oncolytic RNA viruses and particularly alphaviruses have been evaluated as delivery vehicles. Immunization studies in experimental rodent models for various cancers includin...

Recent Advances in Hemophilia Gene Therapy

Heterogeneous loss of function mutations at F8 and F9 genes causes X-linked recessive bleeding disorders, hemophilia A (HA) and hemophilia B (HB), respectively. HA is clinically indistinguishable from HB and accounts for more than 80% of hemophilia cases; the former affects 1/5000 and the latter 1/25000 male births worldwide. In Iran, it is estimated that around 4300 HA and 900 HB patients are ...

ژن درمانی Gene Therapy

Arthrogenic Alphaviruses and Inflammatory Myopathies

There is increasing evidence to suggest that viruses have aetiological roles in inflammatory myopathies. It has been reported that viruses, by means of direct infection of the skeletal muscle, can cause myalgias, polymyositis, and virus-associated rhabdomyolysis. It has also been found that some viruses can cause myositis through a secondary immune-mediated phenomenon. In addition, there are em...